National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10746-c

Testing Status of Sodium Fluoride - 10746-C

 

CASRN: 7681-49-4

Formula: F-Na

Synonyms/Common Names

  • Sodium fluoride (NaF)

Known Uses

Insecticide, enamels, glass mixes, steel de-gassing agent, electroplating fluxes, fluoridation of drinking water, disinfecting fermentation apparatus, preserving wood, pastes, manufacture coated paper, dental caries prophylactic (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C55221B)  Report Complete 
    • TR-393 (NIH Number: 91-2848)  (Peer Review Approval 04/26/1990A )
      Toxicology and Carcinogenesis Studies of Sodium Fluoride (CASRN 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking WaterStudies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R&M: 0,25,100,175 PPM.
  • 2 years (Dosed-Water)  (C55221D)  Completed 
    • Citation: Supplemental 2-Year Sodium Fluoride Male Rat Study (available on NTP website http://ntp.niehs.nih.gov/go/16389)
    • Rats: F344/N
    • Dose: Male rats: 0, 250 ppm.

Special Studies

  • C. elegans  (W10746)  Completed 
    • C. elegans
    • Dose: Growth: 0, 0.5, .79, 1.3, 2, 3.2, 5, 7.9, 13, 20, 32, 50 mM Repro: 0, 0.5, .79, 1.3, 2, 3.2, 5, 7.9, 13, 20, 32, 50 mM Feeding: 0, 0.5, .79, 1.3, 2, 3.2, 5, 7.9, 13, 20, 32, 50 mM.

Genetic Toxicology

  • Chromosome Aberrations  (A12928)  Completed 
    • Mice
    •  Negative (Nonstandard Protocol) 
  • In Vitro Cytogenetics (CA/SCE)  (510381)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Positive 
  • In Vitro Cytogenetics (CA/SCE)  (665475)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (855441)  Completed 
    • Citation: Caspary, W., Myhr, B., Bowers, L., McGregor, D., Riach, C., and Brown, A. Mutagenic activity of fluorides in mouse lymphoma cells. Mutation Res. Vol. 187 (1987) 165-180
    • Mice
    •  Positive 
  • Mouse Lymphoma  (932658)  Completed 
    • Mice
    •  Positive 
  • Micronucleus  (A12928)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (687373)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

Organ Systems Toxicity

  • Conventional Teratology (Dosed-Water)  (TER91022)  Completed 
    • Citation: Final Report on the Developmental Toxicity of Sodium Fluoride in Sprague-Dawley (CD) Rats
    • Citation: Final Report on the Developmental Toxicity of Sodium Fluoride in Sprague-Dawley (CD) Rats
    • Rats: Sprague Dawley
    • Rats Maternal Inadequate 
    • Rats Fetal Negative 
    • Dose: 0, 50, 150, 300 PPM.
  • Conventional Teratology (Dosed-Water)  (TER91033)  Completed 
    • Citation: Final Report on the Developmental Toxicity of Sodium Fluoride in New Zealand White Rabbits
    • Citation: Final Report on the Developmental Toxicity of Sodium Fluoride in New Zealand White Rabbits
    • Rabbit: New Zealand White
    • Rabbits Maternal Positive 
    • Rabbits Fetal Positive 
    • Dose: 0, 100, 200, and 400 ppm.
  • Conventional Teratology (Dosed-Water)  (TER91131)  Completed 
    • Rabbit: New Zealand White
    • Rabbits Maternal Positive 
    • Rabbits Fetal Positive 
    • Dose: I: 0, 50, 300, 500 PPM OR II: 0, 50, 150, 300 PPM.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.