Testing Status of Stannous chloride 10747-F

 

CASRN: 7772-99-8

Formula: Cl2-Sn

Synonyms/Common Names

  • Tin chloride (9CI)

Known Uses

Reducing agent, in manufacture dyes, in glass & plastics manufacture, as mordant in dyes, in manufacture of tin chemicals, color pigments, pharmaceuticals, paper, lubricating oil, tanning agent, reagent, catalyst (Merck 1989).

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C02722)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C02722)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 500, 7500, M: 0, 1900, 30000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C02722)  Report Complete 
    • TR-231 (NIH Number: 82-1787)  (Peer Review Approval 06/23/1981A )
      Carcinogenesis Bioassay of Stannous Chloride (CASRN 7772-99-8) in F344/N Rats and B6C3F1/N Mice (Feed Study)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0, 1000, 2000 PPM/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (685652)  Completed 
    • Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
    • Mice
    •  Positive 
  • In Vitro Cytogenetics (CA/SCE)  (421347)  Completed 
    • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (362954)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (671517)  Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    • Mice
    •  Negative 
  • Micronucleus  (225751)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (741984)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Sister Chromatid Exchanges  (685652)  Completed 
    • Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
    • Mice
    • Sister Chromatid  Positive