National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10749-n

Testing Status of Aspirin, phenacetin, and caffeine - 10749-N

 

CASRN: 8003-03-0

Formula: C10-H13-N-O2.C9-H8-O4.C8-H10-N4-O2

Synonyms/Common Names

  • APC

Known Uses

Analgesic

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C02697)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C02697)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,0.09,1.42 %/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C02697)  Report Complete 
    • TR-067 (NIH Number: 78-1317)  (Peer Review Approval 03/07/1978A )
      Bioassay of a Mixture of Aspirin, Phenacetin, and Caffeine for Possible Carcinogenicity (CASRN 8003-03-0)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Equivocal 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0,0.7,1.4 %/50 PER GROUP.

Genetic Toxicology

  • Salmonella  (N-9387)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
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