National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10752-t

Testing Status of Guar gum - 10752-T

 

CASRN: 9000-30-0

Formula: N/F

Synonyms/Common Names

  • V-7E

Known Uses

Food additive, cosmetic stabilizer, pharmaceutical tablet binder. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C50395)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C50395)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 6300, 100000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C50395)  Report Complete 
    • TR-229 (NIH Number: 82-1785)  (Peer Review Approval 02/18/1981A )
      Carcinogenesis Bioassay of Guar Gum (CASRN 9000-30-0) in F344 Rats and B6C3F1 Mice (Feed Study)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0, 25000, 50000 PPM/50 PER GROUP.

Genetic Toxicology

  • Salmonella  (301651)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 
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