Testing Status of Locust bean gum 10753-X

 

CASRN: 9000-40-2

Formula: N/F

Synonyms/Common Names

  • Carob gum (9CI)

Known Uses

Stabilizer, thickener, binder in foods & cosmetics, pharmaceutic agent, in paints, in treatment of diarrhea (Merck). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C50419)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C50419)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 6300, 100000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C50419)  Report Complete 
    • TR-221 (NIH Number: 82-1777)  (Peer Review Approval 10/15/1980A )
      Carcinogenesis Bioassay of Locust Bean Gum (CASRN 9000-40-2) in F344 Rats and B6C3F1 Mice (Feed Study)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0, 25000, 50000 PPM/50 PER GROUP.

Genetic Toxicology

  • Salmonella  (945885)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative