Testing Status of Phosphamidon 10763-F

 

CASRN: 13171-21-6

Formula: C10-H19-Cl-N-O5-P

Synonyms/Common Names

  • Phosphoric acid,2-chloro-3-(diethylamino)-1-methyl-3-oxo-1-propenyl dimethyl ester (9CI)

Known Uses

Pesticide, cholinesterase inhibitor (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00588)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00588)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: 0, 10, 1280 (AVG) PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00588)  Report Complete 
    • TR-016 (NIH Number: 79-816)  (Peer Review Approval 07/25/1977A )
      Bioassay of Phosphamidon for Possible Carcinogenicity (CASRN 13171-21-6)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Equivocal 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0, 80, 160 PPM/50 PER GROUP.

Genetic Toxicology

  • Salmonella  (607160)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive