National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10772-j

Testing Status of Lead dimethyldithiocarbamate - 10772-J

 

CASRN: 19010-66-3

Formula: C6-H12-N2-Pb-S4

Synonyms/Common Names

  • Bis(dimethylcarbamodithioato-S,S')-lead, (T-4) (9CI)

Known Uses

Vulcanization. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Feed)  (C02891)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 62, 500, M: 0, 62, 250 PPM/51 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C02891)  Report Complete 
    • TR-151 (NIH Number: 79-1707)  (Peer Review Approval 12/13/1978A )
      Bioassay of Lead Dimethyldithiocarbamate for Possible Carcinogenicity (CASRN 19010-66-3)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0, 25, 50 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (615571)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • In Vitro Cytogenetics (CA/SCE)  (962975)  Completed 
    • Sister Chromatid Exchange Not a Valid Test 
    • Chromosome Aberrations Positive 
  • Drosophila  (259202)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (247220)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
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