National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10775-w

Testing Status of p-Anisidine hydrochloride - 10775-W

 

CASRN: 20265-97-8

Related: TRANSGENIC MODEL EVALUATION (P-ANISIDINE HCL)

Formula: C7-H9-N-O.Cl-H

Synonyms/Common Names

  • 4-Methoxybenzenamine hydrochloride

Known Uses

Manufacture of azo dyes

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03758)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03758)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 0.1, 3.0 %/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03758)  Report Complete 
    • TR-116 (NIH Number: 78-1371)  (Peer Review Approval 04/26/1978A )
      Bioassay of p-Anisidine Hydrochloride for Possible Carcinogenicity (CASRN 20265-97-8)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, .3, .6, M: 0, .5, 1.0 %/55 PER GROUP.

Genetic Toxicology

  • Mouse Lymphoma  (802685)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (N-9339)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
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