National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10776-a

Testing Status of 3,3'-Dimethoxybenzidine dihydrochloride - 10776-A

 

CASRN: 20325-40-0

Related: 3,3'-DIMETHOXYBENZIDINE 119-90-4

Formula: C14-H16-N2-O2.2Cl-H

Synonyms/Common Names

  • 3,3'-Dimethoxy-(1,1-biphenyl)-4,4'-diamine dihydrochloride

Known Uses

Production of dyes

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Water)  (C99989)  Completed 
    • Rats: F344/N
  • 13-Week (Dosed-Water)  (C99989)  Completed 
    • Rats: F344/N

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C99989)  Report Complete 
    • TR-372 (NIH Number: 89-2827)  (Peer Review Approval 06/27/1989A )
      Toxicology and Carcinogenesis Studies of 3,3'-Dimethoxybenzidine Dihydrochloride (CASRN 20325-40-0) in F344/N Rats (Drinking Water Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
    • Dose: R: 0,80,170,330 PPM /70,45,75,70 PER GROUP RESPECTIVELY.

Special Studies

  • Metabolism (Dosed-Feed)  (S0017)  Completed 
    • Citation: Lynn RK, Donielson DW, Ilias AM, Kennish JM, Wong K, Matthews HB. Metabolism of bisazobiphenyl dyes derived from benzidine, 3,3'-dimethylbenzidine or 3,3'-dimethoxybenzidine to carcinogenic aromatic amines in the dog and rat. Toxicol Appl Pharmacol. 1980 Nov;56(2):248-58.Pubmed Abstract
    • Rats; Dog

Genetic Toxicology

  • Mouse Lymphoma  (640872)  Completed 
    • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
    • Mice
  • Mouse Lymphoma  (948661)  Completed 
    • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
    • Mice
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