National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10783-w

Testing Status of 11-Aminoundecanoic acid - 10783-W

 

CASRN: 2432-99-7

Formula: C11-H23-N-O2

Synonyms/Common Names

  • Undecanoic acid, 11-amino-

Known Uses

Monomer for nylon 11

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C50613)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C50613)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 9000, 21000, M: 0, 9000, 20000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C50613)  Report Complete 
    • TR-216 (NIH Number: 82-1772)  (Peer Review Approval 02/18/1981A )
      Carcinogenesis Bioassay of 11-Aminoundecanoic Acid (CASRN 2432-99-7) in F344 Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Negative 
      • Male Mice Equivocal 
      • Female Mice Negative 
    • Dose: 0, 7500, 15000 PPM/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (379527)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (084118)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (221003)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (350805)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Negative 
  • Micronucleus  (579120)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (187844)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.