National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10790-s

Testing Status of 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin - 10790-S

 

CASRN: 57653-85-7

Formula: C12-H2-Cl6-O2

Synonyms/Common Names

  • 1,2,3,6,7,8-Hexachlorodibenzo(b,e)(1,4)dioxin (9CI)

Known Uses

Not used commercially in the U.S. contaminant of herbicides. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C03703A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 14-Day (Topical Application)  (C03703B)  Completed 
    • Mice: Swiss Webster
  • 13-Week (Gavage)  (C03703A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0,2.5,100, M: 0,1.25,50 UG/KG/10 PER GROUP.
  • 13-Week (Topical Application)  (C03703B)  Completed 
    • Mice: Swiss Webster
    • Dose: 0,.01,50 UG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C03703A)  Report Complete 
    • TR-198 (NIH Number: 80-1754)  (Peer Review Approval 02/15/1980A )
      Bioassay of a Mixture of 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin and 1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin (Gavage) for Possible Carcinogenicity (CASRN 57653-85-7, CASRN 19408-74-3)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R&MM: 0,1.25,2.5,5.0, FM: 0,2.5,5.0,10.0 UG/KG/50 PER GROUP.
  • 2-Year (Topical Application)  (C03703B)  Report Complete 
    • TR-202 (NIH Number: 80-1758)  (Peer Review Approval 02/15/1980A )
      Bioassay of a Mixture of 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin and 1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin (Dermal Study) for Possible Carcinogenicity (CASRN 57653-85-7; CASRN 19408-74-3)
    • Mice: Swiss Webster
    • Carcinogenesis Results
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0,.005,.01 UG/60 PER GROUP.

Organ Systems Toxicity

  • 14 days Immunotoxicity (Gavage)  (IMM84001)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 0.056, 0.56 or 5.6 ug/kg HCDD and 0.86 ug/kg TCDD.
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