National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10800-c

Testing Status of Polybrominated biphenyl mixture (Firemaster FF-1) - 10800-C

 

CASRN: 67774-32-7

Related: CASNO 36355-01-8

Formula: N/F

Synonyms/Common Names

  • Firemaster FF-1
  • Hexabromobiphenyl, technical grade

Known Uses

Major use as flame retardant for synthetic fibers & plastics

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C53634A)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C53634A)  Report Complete 
    • TR-244 (NIH Number: 83-1800)  (Peer Review Approval 06/23/1981A )
      Toxicology and Carcinogenesis Studies of a Polybrominated Biphenyl Mixture (Firemaster FF-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: 0,0.1,0.3,1.0,3.0,10.0 MG/KG/50 PER GROUP.
  • 2 years (Dosed-Feed)  (C53634B)  Report Complete 
    • TR-398 (NIH Number: 93-2853)  (Peer Review Approval 06/23/1992A )
      Toxicology and Carcinogenesis Studies of Polybrominated Biphenyls (Firemaster FF-1") (CASRN 67774-32-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R & M: 0, 1, 3, 10, AND 30 PPM/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0520)  Completed 
    • Citation: Birnbaum LS, Darcey DJ, McKinney JD. Hexabromonaphthalene contaminants of polybrominated biphenyls: chemical composition and disposition in the rat. J Toxicol Environ Health. 1983 Oct-Dec;12(4-6):555-73.Pubmed Abstract
    • Rats
  • Toxicokinetic Study (Gavage; Intravenous; in-vitro)  (S0239)  Completed 
    • Rats; Human (Cell Lines)

Genetic Toxicology

  • Chromosome Aberrations  (103512)  Completed 
    • Mice
    •  Negative 
  • Drosophila  (537824)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (152414)  Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    • Mice
    •  Negative 
  • Micronucleus  (338141)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Sister Chromatid Exchanges  (103512)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol) 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.