Testing Status of Coconut oil acid diethanolamine condensate 10802-J

 

CASRN: 68603-42-9

Formula: Rc N(CH2CH2OH)2

Synonyms/Common Names

  • Amides, coco, N,N-bis(hydroxyethyl)
  • Coconut diethanolamide
  • Coconut oil acid diethanolamine (con 2/1)
  • Coconut oil acid/diethanolamine condensate

Known Uses

Foam stabilizer in shampoos and dishwashing liquids. Dyeing assistant in textile processing.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Topical Application)  (C55312B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 25, 50, 100, 200, or 400 mg/kg; 20/sex/group M: 0, 50, 100, 200, 400, or 800 mg/kg; 10/sex/group.

Long-Term Carcinogenicity

  • 2 years (Topical Application)  (C55312B)  Report Complete 
    • TR-479 (NIH Number: 01-3969)  (Peer Review Approval 12/10/1997A )
      Toxicology and Carcinogenesis Studies of Coconut Oil Acid Diethanolamine Condensate (CASRN 68603-42-9) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 50, or 100 mg/kg M: 0, 100, or 200 mg/kg (50 sex/species/group).

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (898613)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (876640)  Completed 
    • Mice
    •  Negative 
  • Micronucleus  (A44271)  Completed 
    • Mice: B6C3F1
    • Male Positive 
    • Female Positive 
  • Salmonella  (104376)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative