National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10804-s

Testing Status of Aroclor 1254 - 10804-S

 

CASRN: 11097-69-1

Formula: C12-H5-Cl5

Synonyms/Common Names

  • Polychlorobiphenyls (54% chlorine)

Known Uses

Aroclor® is the registered trademark of the Monsanto Chemical Company for their polychlorinated biphenyls (PCBs). PCBs were developed in 1929 primarily for use as heat transfer fluids and dielectrics (insulators). [Pesticide]

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C02664)  Completed 
    • Rats: F344/N
  • 13 weeks (Dosed-Feed)  (C02664)  Completed 
    • Rats: F344/N
    • Dose: 0,25,400 PPM/15 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C02664)  Report Complete 
    • TR-038 (NIH Number: 78-838)  (Peer Review Approval 11/28/1977A )
      Bioassay of Aroclor® for Possible Carcinogenicity (CASRN 27323-18-8)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Equivocal 
    • Dose: 0,25,50,100 PPM/24 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (166234)  Completed 
    • Mice
    •  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (207552)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • In Vitro Cytogenetics (CA/SCE)  (783442)  Completed 
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (166234)  Completed 
    • Mice: B6C3F1
    • Male Not a Valid Test 
  • Micronucleus  (973822)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (101496)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 
  • Salmonella  (N-9140)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251
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