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Testing Status of Diazepam 10818-R

 

CASRN: 439-14-5

Formula: C16-H13-Cl-N2-O

Synonyms/Common Names

  • 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl-
  • Valium

Known Uses

Medicinal in treatment of anxiety. Skeletal muscle relaxant. Pre-anesthetic drug for childbirth. Hypnotic. Antiepileptic agent.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (048662)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Salmonella  (514151)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 

Organ Systems Toxicity

  • single Dominant Lethal (Male) (Intraperitoneal Injection)  (DLM94001)  Completed 
    • Male Mice: (C3H X 101)F1
    • Mice Male Negative 
    • Dose: 120 MG/KG.
  • greater than 120 days Continuous Breeding (Legacy) (Dosed-Feed)  (RACB90014)  Completed 
    • Citation: Final Report on the Reproductive Toxicity of Diazepam in CD Sprague-Dawley Rats
    • Male and Female Rats: Sprague Dawley
    • Dose: .4% (HIGHEST); 0, 04, .13, .38%; N/A; 0, .38%.
  • Total Reproductive Capacity (Gavage)  (TRC98010)  Completed 
    • Female Mice
    • Mice Female Negative