National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10824-h

Testing Status of Allyl glycidyl ether - 10824-H

 

CASRN: 106-92-3

Formula: C6-H10-O2

Synonyms/Common Names

  • Oxirane, ((2-propenyloxy)methyl)-

Known Uses

Stabilizer of chlorinated compounds, vinyl resins, rubber; resin intermediate.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Inhalation)  (C56666)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Inhalation)  (C56666)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C56666)  Report Complete 
    • TR-376 (NIH Number: 90-2831)  (Peer Review Approval 06/27/1989A )
      Toxicology and Carcinogenesis Studies of Allyl Glycidyl Ether (CASRN 106-92-3) in Osborne-Mendel Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats No Evidence 
      • Male Mice Some Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: R&M: 0,5,10 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (691488)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (486088)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Micronucleus  (446759)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Micronucleus  (A65776)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (838866)  Completed 
    • Citation: Canter, D.A., Zeiger, E., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Comparative mutagenicity of aliphatic epoxides in Salmonella Mutation Res. Vol. 172 (1986) 105-138
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.