National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10834-r

Testing Status of Dieldrin - 10834-R

 

CASRN: 60-57-1

Formula: C12-H8-Cl6-O

Synonyms/Common Names

  • 3,4,5,6,9,9-Hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-2,7:3,6-dimethanonaphth(2,3-b)oxirene

Known Uses

Insecticide formerly used & manufacture in U.S. (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00124A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 14-Day (Dosed-Feed)  (C00124B)  Completed 
    • Rats: F344/N
  • 13-Week (Dosed-Feed)  (C00124A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 40, 320, M: 0, 2.5, 40 PPM/10 PER GROUP.
  • 13-Week (Dosed-Feed)  (C00124B)  Completed 
    • Rats: F344/N
    • Dose: 0, 25, 300 PPM/30 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00124A)  Report Complete 
    • TR-021 (NIH Number: 78-821)  (Peer Review Approval 09/26/1977A )
      Bioassays of Aldrin and Dieldrin for Possible Carcinogenicity (CASRN 309-00-2) (CASRN 60-57-1)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Equivocal 
      • Female Mice Negative 
    • Dose: R: 0, 30, 60, M: 0, 2.5, 5 PPM/50 PER GROUP.
  • 109 weeks (Dosed-Feed)  (C00124B)  Report Complete 
    • TR-022 (NIH Number: 78-822)  (Peer Review Approval 11/28/1977A )
      Bioassay of Dieldrin for Possible Carcinogenicity (CASRN 60-57-1)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
    • Dose: 0, 2, 10, 50 PPM/48 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (268228)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (145014)  Completed 
    • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
    • Mice
    •  Positive 
  • Salmonella  (210083)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.