National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10837-d

Testing Status of Dibromomannitol - 10837-D

 

CASRN: 488-41-5

Formula: C6-H12-Br2-O4

Synonyms/Common Names

  • 1,6-Dibromo-1,6-dideoxy-D-mannitol

Known Uses

Chemotherapeutic agent

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C04762)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss
  • 13-Week (Intraperitoneal Injection)  (C04762)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C04762)  Report Complete 
    •   (Peer Review Approval NA) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
    • Rats: Sprague Dawley; Mice: Swiss

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (953018)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (363594)  Completed 
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • Drosophila  (578911)  Completed 
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Positive 
  • Micronucleus  (557052)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (119893)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
  • Salmonella  (692151)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
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