National Toxicology Program

National Toxicology Program

Testing Status of Diarylanilide yellow - 10839-K


CASRN: 6358-85-6

Formula: C32-H26-Cl2-N6-O4

Synonyms/Common Names

  • C.I. Pigment Yellow 12
  • 2,2'-((3,3'-Dichloro(1,1'-biphenyl)-4,4'-diyl)-bis(azo))bis(3-oxo-N-phenyl)-butanamide
  • Yellow 12, C.I. Pigment

Known Uses

Dye for paint, ink, plastic, rubber

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03269)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03269)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03269)  Report Complete 
    • TR-030 (NIH Number: 78-830)  (Peer Review Approval 09/26/1977A )
      Bioassay of Diarylanilide Yellow for Possible Carcinogenicity (CASRN 6358-85-6)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (659162)  Completed 
    • Sister Chromatid Exchange Equivocal 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (566314)  Completed 
    • Mice
    •  Negative 
  • Salmonella  (983137)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
  • Salmonella Reduction  (637663)  Completed 
    • Citation: Reid, T., Morton K., and King, C. Mutagenicity of azo dyes following metabolism by different reductive/oxidative systems. Environ. Mutagen. Vol. 6 (1984) 705-717
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.