National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10840-h

Testing Status of Dacarbazine - 10840-H

 

CASRN: 4342-03-4

Formula: C6-H10-N6-O

Synonyms/Common Names

  • DIC
  • 1H-Imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-

Known Uses

Chemotherapeutic agent

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C04717)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss
  • 13-Week (Intraperitoneal Injection)  (C04717)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C04717)  Report Complete 
    •   (Peer Review Approval NA) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
    • Rats: Sprague Dawley; Mice: Swiss

Genetic Toxicology

  • Salmonella  (003765)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive 
  • Salmonella  (685439)  Completed 
    •  Positive 
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