National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10847-k

Testing Status of Chlorpropamide - 10847-K

 

CASRN: 94-20-2

Formula: C10-H13-Cl-N2-O3-S

Synonyms/Common Names

  • 4-Chloro-N-((propylamino)carbonyl)benzenesulfonamide

Known Uses

Hypoglycemic agent

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01752)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C01752)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 1200, 30000, M: 0, 2000, 50000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C01752)  Report Complete 
    • TR-045 (NIH Number: 78-845)  (Peer Review Approval 11/28/1977A )
      Bioassay of Chlorpropamide for Possible Carcinogenicity (CASRN 94-20-2)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 300, 6000, M: 0, 3317, 6635 (AVG) PPM/35 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (952992)  Completed 
    • Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (920836)  Completed 
    • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
    • Mice
    •  Negative 
  • Salmonella  (709688)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.