National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10848-p

Testing Status of Chloropicrin - 10848-P

 

CASRN: 76-06-2

Formula: C-Cl3-N-O2

Synonyms/Common Names

  • Trichloronitromethane

Known Uses

Fumigant; fungicide; insecticide; organic synthesis; dyes; tear gas. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C00533)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Gavage)  (C00533)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C00533)  Report Complete 
    • TR-065 (NIH Number: 78-1315)  (Peer Review Approval 01/18/1978A )
      Bioassay of Chloropicrin for Possible Carcinogenicity (CASRN 76-06-2)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Inadequate 
      • Female Rats Inadequate 
      • Male Mice Negative 
      • Female Mice Negative 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (405202)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (149367)  Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
  • Salmonella  (643495)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
  • Salmonella  (678673)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.