Testing Status of Nitromethane 10851-V

 

CASRN: 75-52-5

Formula: C-H3-N-O2

Synonyms/Common Names

  • Nitrocarbol

Known Uses

Fuel additive and propellant; synthesis intermediate for agricultural fumigants, intermediate for nitro and amino alcohols, biocides, and other products; cellulosic compound solvent; explosive in mining, oil-well drilling, and seismic exploration. Detected in air, surface and drinking water, and in cigarette smoke. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C61927)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 94, 188, 375, 750, OR 1500 PPM (5/S/S).
  • 13 weeks (Inhalation)  (C61927)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 94, 188, 375, 750, OR 1500 PPM; RATS 20/GROUP, MICE 10/GROUP.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C61927)  Report Complete 
    • TR-461 (NIH Number: 97-3377)  (Peer Review Approval 12/05/1995A )
      Toxicology and Carcinogenesis Studies of Nitromethane (CASRN 75-52-5) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 94, 188, OR 375 PPM; 50/GROUP M: 0, 188, 375, OR 750 PPM; 50/GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (703142)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A55749)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (860172)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative