National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10853-d

Testing Status of Nithiazide - 10853-D

 

CASRN: 139-94-6

Formula: C6-H8-N4-O3-S

Synonyms/Common Names

  • N-Ethyl-N'-(5-nitro-2-thiazoylyl)urea (9CI)

Known Uses

Antiprotozoal compound in veterinary medicine.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03792)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03792)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,464,21500, M: 0,6800,31500 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03792)  Report Complete 
    • TR-146 (NIH Number: 79-1702)  (Peer Review Approval 10/25/1978A )
      Bioassay of Nithiazide for Possible Carcinogenicity (CASRN 139-94-6)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Equivocal 
    • Dose: R: 0,625,1250, M: 0,2500,5000 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (552942)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (343608)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.