National Toxicology Program

National Toxicology Program

Testing Status of N-Phenyl-p-phenylenediamine - 10855-K


CASRN: 101-54-2

Formula: C12-H12-N2

Synonyms/Common Names

  • N-Phenyl-1,4-benzenediamine (9CI)

Known Uses

Industrial intermediate, hair dyes. Used in the production of several different chemical products. It is an intermediate for photographic chemicals, pharmaceuticals, microbicides, and other organics; it is used in the manufacture of dyes and dye reagents; and it reacts with ketones to form derivatives of p-phenylenediamine which are used as antiozonants in rubber. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C02233)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C02233)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C02233)  Report Complete 
    • TR-082 (NIH Number: 78-1332)  (Peer Review Approval 03/06/1978A )
      Bioassay of N-Phenyl-p-phenylenediamine for Possible Carcinogenicity (CASRN 101-54-2)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (887002)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (867606)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (231064)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.