National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10862-g

Testing Status of 4,4'-Methylenedianiline dihydrochloride - 10862-G

 

CASRN: 13552-44-8

Formula: C13-H14-N2.2Cl-H

Synonyms/Common Names

  • 4,4'-Methylenebisbenzenamine dihydrochloride (9CI)

Known Uses

Intermediate for isocyanates and polyisocyanates

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Water)  (C54604)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Water)  (C54604)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 50, 800, M: 0, 25, 400 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Water)  (C54604)  Report Complete 
    • TR-248 (NIH Number: 83-2504)  (Peer Review Approval 06/16/1982A )
      Carcinogenesis Studies of 4,4'-Methylenedianiline Dihydrochloride (CASRN 13552-44-8) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: 0, 150, 300 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (204381)  Completed 
    • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (589444)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Mouse Lymphoma  (641032)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Salmonella  (735526)  Completed 
    •  Positive 
  • Salmonella  (786789)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive 
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