National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10864-p

Testing Status of m-Nitrotoluene - 10864-P

 

CASRN: 99-08-1

Formula: C7-H7-N-O2

Synonyms/Common Names

  • 1-Methyl-3-nitrobenzene (9CI)
  • 3-Nitrotoluene

Known Uses

Manufacture of dyes. Synthesis of explosives. Chemical intermediate. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C62351)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C62351)  Report Complete 
    • TOX-23 (NIH Number: 93-3346)
      Toxicity Studies of o-,m-, and p- Nitrotoluenes (CASRNs 88-72-2, 99-08-1, 99-99-0) Administered in Dosed Feed to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 625, 1250, 2500, 5000, 10000 PPM/10 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0642)  Completed 
    • Citation: Comparative Metabolism and Excretion of [14C] M-Nitrotoluence in Rats and Mice.
    • Male and Female Rats: F344/N; Male and Female Mice

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (713359)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A90482)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A96144)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Salmonella  (142570)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

Organ Systems Toxicity

  • 14 days Immunotoxicity (Gavage)  (IMM95002)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 200, 400, OR 600 MG/KG; POSITIVE CONTROL (O-NITROTOLUENE) AT 600 MG/KG.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.