National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10865-t

Testing Status of Lindane - 10865-T

 

CASRN: 58-89-9

Formula: C6-H6-Cl6

Synonyms/Common Names

  • (1alpha,2alpha,3beta,4alpha,5alpha,6beta)-1,2,3,4,5,6-hexachloro-cyclohexane (9CI)
  • Gama-HCH
  • Gamma-BHC

Known Uses

Insecticide, pediculicide, scabicide (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00204)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00204)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 160, 2560, M: 0, 40, 1280 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00204)  Report Complete 
    • TR-014 (NIH Number: 77-814)  (Peer Review Approval 07/25/1977A )
      Bioassay of Lindane for Possible Carcinogenicity (CASRN 58-89-9)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: MR: 0, 236, 472 (AVG), FR: 0, 135, 270 (AVG), M: 0, 80, 160 PPM/50 PER GROUP.

Special Studies

  • C. elegans  (S0929)  Completed 
    • C. elegans
    • Dose: feed (0, .025, .032, .04, .05, .063, .079, .1, .13, .16, .20, .25) mM 11/02/06repro (0, .01, .016, .025, .04, .063, .1, .16, .25, .4, .63, 1) mM 02/23/06GROWTH: (0, .01, .016, .025, .04, .063, .1, .16, .25, .4, .63, 1) mM 06/27/07.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (931320)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (849017)  Completed 
    • Mice
    •  Equivocal 
  • Salmonella  (946710)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.