National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10868-f

Testing Status of Lasiocarpine - 10868-F

 

CASRN: 303-34-4

Formula: C21-H33-N-O7

Synonyms/Common Names

  • 7-((2,3-Dihydroxy-2-(1-methoxyethyl)-3-methyl-1-oxobutoxy)methyl)-2-butanoic acid (9CI)

Known Uses

Carcinogen in research, use in India to treat snakebites, as an emetic, hepatotoxic pyrrolizidine (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01478)  Completed 
    • Rats: F344/N
  • 13-Week (Dosed-Feed)  (C01478)  Completed 
    • Rats: F344/N

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C01478)  Report Complete 
    • TR-039 (NIH Number: 78-839)  (Peer Review Approval 11/28/1978A )
      Bioassay of Lasiocarpine for Possible Carcinogenicity (CASRN 303-34-4)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
    • Dose: 0, 7, 15, or 30 ppm/48 per group.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (256879)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (005545)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • Micronucleus  (A44011)  Completed 
    • Female Positive 
  • Salmonella  (270072)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
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