Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Lasiocarpine 10868-F

 

CASRN: 303-34-4

Formula: C21-H33-N-O7

Synonyms/Common Names

  • 7-((2,3-Dihydroxy-2-(1-methoxyethyl)-3-methyl-1-oxobutoxy)methyl)-2-butanoic acid (9CI)

Known Uses

Carcinogen in research, use in India to treat snakebites, as an emetic, hepatotoxic pyrrolizidine (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01478)  Completed 
    • Rats: F344/N
  • 13-Week (Dosed-Feed)  (C01478)  Completed 
    • Rats: F344/N
    • Dose: 0, 5, or 160 ppm/30 per group.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C01478)  Completed 
    • TR-039 (NIH Number: 78-839)  (Peer Review Approval 11/28/1978A )
      Bioassay of Lasiocarpine for Possible Carcinogenicity (CASRN 303-34-4)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
    • Dose: 0, 7, 15, or 30 ppm/48 per group.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (256879)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (005545)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Positive 
  • Micronucleus  (A44011)  Completed 
    • Female Positive 
  • Salmonella  (270072)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive