National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10871-k

Testing Status of Hydroxyurea - 10871-K

 

CASRN: 127-07-1

Formula: C-H4-N2-O2

Synonyms/Common Names

  • SQ 1089

Known Uses

Chemotherapeutic agent

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C04831)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss
  • 13-Week (Intraperitoneal Injection)  (C04831)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C04831)  Report Complete 
    •   (Peer Review Approval NA) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
    • Rats: Sprague Dawley; Mice: Swiss
    • Dose: 0,125,250 MG/KG/25 PER GROUP.

Modified One-Generation

  • GD 17 to PND 28 (dams) twice daily; PND 10 to PND 28 (pups) twice daily Dose Range Finding (Gavage)  (MOG006)  Completed 
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 37.5, 75, 100, 150 mg/kg/day.
  • Developmental Toxicity (Gavage)  (MOG006B)  Assigned 
    • Rats: Harlan Sprague-Dawley
  • F0 Generation (Gavage)  (MOG006B)  Assigned 
    • Rats: Harlan Sprague-Dawley
  • Fertility Assessment (Gavage)  (MOG006B)  Assigned 
    • Rats: Harlan Sprague-Dawley
  • Neurotoxicology Assessment (Gavage)  (MOG006B)  Assigned 
    • Rats: Harlan Sprague-Dawley
  • 13-Week Subchronic (Gavage)  (MOG006B)  Assigned 
    • Rats: Harlan Sprague-Dawley

Special Studies

  • Preliminary Toxicokinetic Study (Gavage)  (K10871)  Completed 
    • Citation: Hydroxyurea Preliminary Toxicokinetic Study Preliminary Toxicokinetic Study Of Hydroxyurea Administered By Gavage To Female Harlan Sprague Dawley (HSD) Rats And Their Pups
    • Male and Female Rats: Harlan Sprague-Dawley
    • Dose: 18.8 and 75 mg/kg/day..

Genetic Toxicology

  • Comet Assay (Gavage)  (G10871B)  Completed 
    • Mice: B6C3F1
  • Comet Assay (Gavage)  (G10871C)  On Test 
    • Mice: B6C3F1
  • Drosophila  (337254)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Micronucleus  (G10871)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (855066)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.