National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10876-f

Testing Status of Guanazole - 10876-F

 

CASRN: 1455-77-2

Formula: C2-H5-N5

Synonyms/Common Names

  • 1H-1,2,4-triazole-3,5-diamine (9CI)

Known Uses

Chemotherapeutic agent

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C04819)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss
  • 13-Week (Intraperitoneal Injection)  (C04819)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C04819)  Report Complete 
    •   (Peer Review Approval 09/00/1977A ) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
    • Rats: Sprague Dawley; Mice: Swiss

Genetic Toxicology

  • Salmonella  (635386)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.