National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10879-s

Testing Status of Endosulfan - 10879-S

 

CASRN: 115-29-7

Formula: C9-H6-Cl6-O3-S

Synonyms/Common Names

  • 6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-, 3-oxide

Known Uses

Insecticide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00566)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00566)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 178, 1780, M: 0, 3.2, 32 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00566)  Report Complete 
    • TR-062 (NIH Number: 78-1312)  (Peer Review Approval 01/18/1978A )
      Bioassay of Endosulfan for Possible Carcinogenicity (CASRN 115-29-7)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Inadequate Study 
      • Female Rats Negative 
      • Male Mice Inadequate Study 
      • Female Mice Negative 
    • Dose: MR: 0, 408, 952 (AVG), FR: 0, 223, 445 (AVG), MM: 0, 3.5, 6.9 (AVG), FM: 0, 2.0, 3.9 (AVG) PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (447920)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (309806)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Salmonella  (670141)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.