National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10882-x

Testing Status of C.I. Direct Brown 95 - 10882-X

 

CASRN: 16071-86-6

Formula: C31-H18-Cu-N6-O9-S.2Na

Synonyms/Common Names

  • Brown 95, C.I. Direct
  • Copper, (5-((4'-((2,5-dihydroxy-4-((2-hydroxy-5-sulfophenyl)azo)phenyl)azo)(1,1'-biphenyl)-4-yl)azo)-2-hydroxybenzoato(2-))-, disodium salt

Known Uses

Dye for textiles, leather, plastics, paper

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C54568)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,190,375,750,1500,3000, MM: 0,750,1500,3000,6000,12500, FM: 0,375,750,1500,3000,6000 PPM/10 PER GROUP.
  • 13-Week (Dosed-Feed)  (C54568)  Report Complete 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,190,375,750,1500,3000, MM: 0,750,1500,3000,6000,12500, FM: 0,375,750,1500,3000,6000 PPM/10 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (754489)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Equivocal 
    • Chromosome Aberrations Negative 
  • Drosophila  (205697)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (162126)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (306945)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Weakly Positive 
  • Salmonella  (870768)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella Reduction  (599630)  Completed 
    • Citation: Reid, T., Morton K., and King, C. Mutagenicity of azo dyes following metabolism by different reductive/oxidative systems. Environ. Mutagen. Vol. 6 (1984) 705-717
    •  Positive 

Organ Systems Toxicity

  • 6 to 15 GD Conventional Teratology (Subcutaneous Injection)  (T0139)  Completed 
    • Female Mice: Swiss
    • Dose: 0, 20, 40, 60, 80, 100 MG/KG/DAY.
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