National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10883-c

Testing Status of C.I. Direct Blue 6 - 10883-C

 

CASRN: 2602-46-2

Formula: C32-H24-N6-O14-S4.4Na

Synonyms/Common Names

  • 3,3'-((1,1'-biphenyl)-4,4'-diylbis(azo))bis(5-amino-4-hydroxy-, tetrasodium salt
  • Blue 6, C.I. Direct

Known Uses

Dye for textiles, leather, ink; biological and wood stains; hair dyes (formerly used)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C54579A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 190, 375, 750, 1500, OR 3000 PPM M: 0, 750, 1500, 3000, 6000, OR 12500 PPM; 10 PER GROUP.
  • 13 weeks (Dosed-Feed)  (C54579A)  Report Complete 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 750, 1500, 2000, 6000, OR 12500 PPM M: 0, 190, 375, 750, 1500, OR 3000 PPM.
  • 13-Week (Dosed-Water)  (C54579B)  Completed 
    • Rats: F344/N
    • Dose: 0, .019, .3 %/10 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (160428)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (831122)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (241000)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (849964)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella Reduction  (461569)  Completed 
    • Citation: Reid, T., Morton K., and King, C. Mutagenicity of azo dyes following metabolism by different reductive/oxidative systems. Environ. Mutagen. Vol. 6 (1984) 705-717
    •  Positive 

Organ Systems Toxicity

  • 6 to 15 GD Conventional Teratology (Subcutaneous Injection)  (T0123)  Completed 
    • Female Mice: Swiss
    • Dose: 0, 50, 75, 100, 200 MG/KG/DAY.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.