National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10886-n

Testing Status of C.I. Direct Black 38 - 10886-N

 

CASRN: 1937-37-7

Formula: C34-H27-N9-O7-S2.2Na

Synonyms/Common Names

  • 4-amino-3-((4'-((2,4-diaminophenyl)azo)(1,1'-biphenyl)-4-yl)azo)-5-hydroxy-6-(phenylazo)-, disodium salt
  • Black 38, C.I. Acid

Known Uses

Dye for textiles, leather, ink; biological and wood stains; hair dyes (formerly used)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C54557)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C54557)  Report Complete 
    • Rats: F344/N; Mice: B6C3F1

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (325575)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Salmonella  (604832)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
  • Salmonella  (921044)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
  • Salmonella Reduction  (915213)  Completed 
    • Citation: Reid, T., Morton K., and King, C. Mutagenicity of azo dyes following metabolism by different reductive/oxidative systems. Environ. Mutagen. Vol. 6 (1984) 705-717
    •  Positive 

Organ Systems Toxicity

  • 6 to 15 GD Conventional Teratology (Subcutaneous Injection)  (T0121)  Completed 
    • Female Mice: Swiss
    • Dose: 0, 100, 150, 200, 300, 400 MG/KG/DAY.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.