National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10888-w

Testing Status of Dimethoate - 10888-W

 

CASRN: 60-51-5

Formula: C5-H12-N-O3-P-S2

Synonyms/Common Names

  • O,O-Dimethyldithiophosphorylacetic acid (2-(methylamino)-2-oxoethyl) ester

Known Uses

Systemic and contact insecticide (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00135)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00135)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00135)  Report Complete 
    • TR-004 (NIH Number: 77-804)  (Peer Review Approval NA)
      Bioassay of Dimethoate for Possible Carcinogenicity (CASRN 60-51-5)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 

Special Studies

  • Cell Proliferation (Dosed-Feed)  (S0180)  Completed 
    • Citation: Cunningham ML, Elwell MR, Matthews HB. Relationship of carcinogenicity and cellular proliferation induced by mutagenic noncarcinogens vs carcinogens. III. Organophosphate pesticides vs tris(2,3-dibromopropyl)phosphate. Fundam Appl Toxicol. 1994 Oct;23(3):363-9.Pubmed Abstract
    • Male Rats: F344/N

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (171898)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Equivocal 
  • Salmonella  (095135)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
  • Salmonella  (190513)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
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