Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of 5-Azacytidine 10889-A

 

CASRN: 320-67-2

Formula: C8-H12-N4-O5

Synonyms/Common Names

  • 4-Amino-1-beta-D-ribofuranosyl-1,3,5-traizin-2(1H)-one
  • 5-AzaC
  • Azacitidine

Known Uses

Anticancer drug and antibiotic

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C01569)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
  • 13-Week (Intraperitoneal Injection)  (C01569)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Dose: FR: 0, 0.13, 2.6, MM: 0, .22, 4.4, FM: 0, 4.4, 35.2 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C01569)  Completed 
    • TR-042 (NIH Number: 78-842)  (Peer Review Approval 11/28/1977A )
      Bioassay of 5-Azacytidine for Possible Carcinogenicity (CASRN 320-67-2)
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Inadequate Study 
      • Female Rats Inadequate Study 
      • Male Mice Inadequate Study 
      • Female Mice Positive 
    • Dose: R: 0, 2.6, 5.2, M: 0, 2.2, 4.4 MG/KG/35 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (932806)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (010439)  Completed 
    • Mice
    •  Positive 
  • Micronucleus  (A95392)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (440974)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 
  • Salmonella  (A21960)  Completed 
    •  Positive 

Organ Systems Toxicity

  • Total Reproductive Capacity (Dosed-Feed)  (TRC98004)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice
    • Mice Female Negative