National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10889-a

Testing Status of 5-Azacytidine - 10889-A

 

CASRN: 320-67-2

Formula: C8-H12-N4-O5

Synonyms/Common Names

  • 4-Amino-1-beta-D-ribofuranosyl-1,3,5-traizin-2(1H)-one
  • 5-AzaC

Known Uses

Anticancer drug and antibiotic

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C01569)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
  • 13-Week (Intraperitoneal Injection)  (C01569)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Dose: FR: 0,0.13,2.6, MM: 0,.22,4.4, FM: 0,4.4,35.2 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C01569)  Report Complete 
    • TR-042 (NIH Number: 78-842)  (Peer Review Approval 11/28/1977A )
      Bioassay of 5-Azacytidine for Possible Carcinogenicity (CASRN 320-67-2)
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Inadequate Study 
      • Female Rats Inadequate Study 
      • Male Mice Inadequate Study 
      • Female Mice Positive 
    • Dose: R: 0,2.6,5.2, M: 0,2.2,4.4 MG/KG/35 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (932806)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (010439)  Completed 
    • Mice
    •  Positive 
  • Micronucleus  (A95392)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (440974)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 
  • Salmonella  (A21960)  Completed 
    •  Positive 

Organ Systems Toxicity

  • Total Reproductive Capacity (Dosed-Feed)  (TRC98004)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice
    • Mice Female Negative 
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