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Testing Status of 4,4'-Sulfonyldianiline (Dapsone) 10890-X

 

CASRN: 80-08-0

Formula: C12-H12-N2-O2-S

Synonyms/Common Names

  • DAPSONE
  • Dapsone (AIDS)
  • 4,4'-Sulfonybisbenzenamine (9CI)

Known Uses

Hardening agent for epoxy resins; topical antibacterial agent; treatment of gynecologic neoplasms; antibacterial/antiprotozoal in veterinary medicine, used in treatment of leprosy

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01718)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C01718)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 1200, 30000, M: 0, 2000, 50000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C01718)  Completed 
    • TR-020 (NIH Number: 77-820)  (Peer Review Approval 07/25/1977A )
      Bioassay of Dapsone for Possible Carcinogenicity (CASRN 80-08-0)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 600, 1200, M: 0, 500, 1000 PPM/35 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (954704)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Weakly Positive 
  • In Vitro Cytogenetics (CA/SCE)  (962654)  Completed 
    • Sister Chromatid Exchange Not a Valid Test 
    • Chromosome Aberrations Weakly Positive 
  • Mouse Lymphoma  (001410)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Negative 
  • Salmonella  (318705)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (CV-204)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248

Organ Systems Toxicity

  • Immunotoxicity (Gavage)  (IMM90015)  Completed 
    • Female Mice: C57BL/6
    • Dose: 0, 3.4, 13.5, 54.0 MG/KG.
  • 1 to 31 Repro/Dev Gen Tox (28-Day) (Gavage)  (RACB93157)  Completed 
    • Male and Female Mice: Swiss
    • Dose: N/A; N/A; N/A; N/A.