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Testing Status of 4-Chloro-o-phenylenediamine 10892-F

 

CASRN: 95-83-0

Formula: C6-H7-Cl-N2

Synonyms/Common Names

  • 4-Chloro-1,2-benzenediamine

Known Uses

Oxidation base; chemical intermediate for dyes; (formerly) ingredient in hair dyes; curing agent in epoxy resins (HSDB)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03292)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03292)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, .03, 3.0 %/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03292)  Completed 
    • TR-063 (NIH Number: 78-1313)  (Peer Review Approval 03/06/1978A )
      Bioassay of 4-Chloro-o-phenylenediamine for Possible Carcinogenicity (CASRN 95-83-0)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0, .5, 1.0 (AVG), M: 0, .7, 1.4 (AVG) %DIET/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (970086)  Completed 
    • Mice
    •  Positive (Nonstandard Protocol) 
  • In Vitro Cytogenetics (CA/SCE)  (689355)  Completed 
    • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (A99443)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (200662)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive 
  • Salmonella  (CV-218)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Sister Chromatid Exchanges  (970086)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol) 

Organ Systems Toxicity

  • 14 days Immunotoxicity (Gavage)  (IMM87099)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 50, 200, OR 400 MG/KG.
  • daily for 5 consectuvie days Immunotoxicity (Topical Application & Intraductal Injection)  (IMM89029)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 1, 3, 10%.