National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10898-e

Testing Status of 3-Sulfolene - 10898-E

 

CASRN: 77-79-2

Formula: C4-H6-O2-S

Synonyms/Common Names

  • Thiophene, 2,5-dihydro-, 1,1-dioxide (9CI)

Known Uses

Chemical intermediate; catalyst

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C04557)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Gavage)  (C04557)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 56, 562, M: 0, 316, 3160 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C04557)  Report Complete 
    • TR-102 (NIH Number: 78-1352)  (Peer Review Approval 03/06/1978A )
      Bioassay of 3-Sulfolene for Possible Carcinogenicity (CASRN 77-79-2)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: FR: 0, 120, 240 (AVG), MR: 0, 197, 372 (AVG), FM: 0, 384, 768 (AVG), MM: 0, 311, 622 (AVG) MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (067203)  Completed 
    • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • In Vitro Cytogenetics (CA/SCE)  (080941)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (964398)  Completed 
    • Mice
    •  Negative 
  • Salmonella  (430543)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
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