Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Pyrimethamine 10904-X

 

CASRN: 58-14-0

Formula: C12-H13-Cl-N4

Synonyms/Common Names

  • 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine (9CI)

Known Uses

Antimalarial

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01683)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C01683)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: FR: 0, 100, 1200, FM: 0, 100, 2000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C01683)  Completed 
    • TR-077 (NIH Number: 78-1327)  (Peer Review Approval 01/18/1978A )
      Bioassay of Pyrimethamine for Possible Carcinogenicity (CASRN 58-14-0)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Inadequate Study 
      • Female Mice Negative 
    • Dose: R: 0, 200, 400, M: 0, 500, 1000 PPM/35 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (074874)  Completed 
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (368591)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative