Testing Status of Pyrimethamine 10904-X

 

CASRN: 58-14-0

Formula: C12-H13-Cl-N4

Synonyms/Common Names

  • 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine (9CI)

Known Uses

Antimalarial

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01683)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C01683)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: FR: 0, 100, 1200, FM: 0, 100, 2000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C01683)  Report Complete 
    • TR-077 (NIH Number: 78-1327)  (Peer Review Approval 01/18/1978A )
      Bioassay of Pyrimethamine for Possible Carcinogenicity (CASRN 58-14-0)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Inadequate Study 
      • Female Mice Negative 
    • Dose: R: 0, 200, 400, M: 0, 500, 1000 PPM/35 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (074874)  Completed 
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (368591)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative