National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10910-p

Testing Status of 2-Methyl-1-nitroanthraquinone - 10910-P

 

CASRN: 129-15-7

Formula: C15-H9-N-O4

Synonyms/Common Names

  • 2-Methyl-1-nitro-9,10-Anthracenedione (9CI)

Known Uses

Dye intermediate (formerly)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01923A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 2 weeks (Dosed-Feed)  (C01923B)  Completed 
    • Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C01923A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,0.005,5 %/5 PER GROUP.
  • 13 weeks (Dosed-Feed)  (C01923B)  Completed 
    • Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C01923A)  Report Complete 
    • TR-029 (NIH Number: 78-829)  (Peer Review Approval 11/28/1977A )
      Bioassay of 2-Methyl-1-Nitroanthraquinone for Possible Carcinogenicity (CASRN 129-15-7)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: 0,0.06,0.12 %/50 PER GROUP.
  • 2 years (Dosed-Feed)  (C01923B)  Report Complete 
    •   (Peer Review Approval 11/18/1977A ) Citation: ASK Murthy, JR Baker, ER Smith, GG Wade, Development of Hemangiosarcomas in B6C3F1 Mice Fed 2-Methyl-1-Nitroanthraquinone. Int. J. Cancer 19:117-121 (1977)
    • Mice: B6C3F1
    • Dose: 0,.05,.15,.5,1.5,5.0 %.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (565805)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (693002)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (324967)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.