National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10915-j

Testing Status of 1,1,2,2-Tetrachloroethane - 10915-J

 

CASRN: 79-34-5

Related: HALOGENATED ETHANES CS (1,1,2,2-TETRACHLOROETHANE)

Formula: C2-H2-Cl4

Synonyms/Common Names

  • Acetylene tetrachloride
  • Acetylenetetrachloride
  • TCE

Known Uses

Solvent; soil sterilization; herbicides; insecticides; paints; varnish; metal cleaners and degreasers. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C03554A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 2 weeks (Microencapsulation in Feed)  (C03554B)  Report Review 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 3325, 6650, 13300, 26600, OR 53200 PPM (5/SEX/SPECIES/GROUP).
  • 2 weeks (Gavage)  (C03554C)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 135, 270, OR 540 MG/KG M: 0, 337.5, 675, OR 1350 MG/KG (50/SEX/SPECIES).
  • 13-Week (Gavage)  (C03554A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 56, 562, M: 0, 32, 136 MG/KG/10 PER GROUP.
  • 14 weeks (Microencapsulation in Feed)  (C03554E)  Report Complete 
    • TOX-49 (NIH Number: 04-4414)  (Tox Peer Review 05/23/2002A )
      Toxicity Studies of 1,1,2,2-Tetrachloroethane Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice (CASRN 79-34-5)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: UNTREATED CONTROLS; VEHICLE CONTROLS; 268, 589, 1180, 2300 OR 4600 PPM (RATS) OR 589, 1120, 2300, 4550 OR 9100 PPM (MICE) 10/SEX/SPECIES/GROUP..

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C03554A)  Report Complete 
    • TR-027 (NIH Number: 78-827)  (Peer Review Approval 09/26/1977A )
      Bioassay of 1,1,2,2-Tetrachloroethane for Possible Carcinogenicity (CASRN 79-34-5)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: FR: 0, 43, 76 (AVG), MR: 0, 62, 108 (AVG), M: 0, 142, 284 (AVG) MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (838914)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (959130)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (990809)  Completed 
    • Mice
    •  Negative 
  • Micronucleus  (A72450)  Completed 
    • Mice: B6C3F1
    • Male Positive 
    • Female Positive 
  • Micronucleus  (B72450)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
    • Female Positive 
  • Salmonella  (547949)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (866388)  Completed 
    •  Negative 

Organ Systems Toxicity

  • Teratology Pilot Studies (Dosed-Feed)  (TRP91023)  Completed 
    • Female Mice: Swiss CD-1
    • Dose: 0, 4, 7.5, 10.%.
  • 6 to 16 GD Teratology Pilot Studies (Dosed-Feed)  (TRP91028)  Completed 
    • Female Mice: Swiss CD-1
    • Dose: 0, .0125, .05, .1, .2, OR .3 %.
  • 6 to 16 GD Teratology Pilot Studies (Dosed-Feed)  (TRP91029)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 0.045, 0.135, 0.270, 0.405, OR 0.540%.
  • 6 to 15 GD Teratology Pilot Studies (Dosed-Feed)  (TRP91069)  Completed 
    • Female Mice: Swiss CD-1
    • Dose: 0, .5, 1, 1.5, 2, OR 3%.
  • Teratology Pilot Studies (Gavage)  (TRP92039)  Completed 
    • Rabbit: New Zealand White
    • Dose: 0, 10, 50, 100, 150, 200 MG/KG.
  • Teratology Pilot Studies (Gavage)  (TRP92064)  Completed 
    • Rats
    • Dose: 0, 100, 150, 200, 250 MG/KG.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.