Testing Status of 1-Nitropropane 10918-W

 

CASRN: 108-03-2

Formula: C3-H7-N-O2

Synonyms/Common Names

  • Propane, 1-nitro-

Known Uses

Solvent for cellulose acetate, vinyl resin, synthetic rubber, fats, oils, waxes; gasoline additive. Produced from natural gas (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Cell Proliferation (Gavage)  (S0167)  Completed 
    • Citation: Cunningham ML, Matthews HB. Relationship of hepatocarcinogenicity and hepatocellular proliferation induced by mutagenic noncarcinogens vs carcinogens. II. 1- vs 2-nitropropane. Toxicol Appl Pharmacol. 1991 Sep 15;110(3):505-13.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 0.5, 1.0, 2.0 MMOL/KG.

Genetic Toxicology

  • Salmonella  (276398)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (569172)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative