Testing Status of tris(1,3-Dichloro-2-propyl) phosphate 10923-J

 

CASRN: 13674-87-8

Formula: C9-H15-Cl6-O4-P

Synonyms/Common Names

  • 1,3-Dichloro-2-propanol phosphate (3:1)(9CI)

Known Uses

Flame retardant. In polyesters, rigid urethane foam, resins.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0007)  Completed 
    • Citation: Nomeir AA, Kato S, Matthews HB. The metabolism and disposition of tris(1,3-dichloro-2-propyl) phosphate (Fyrol FR-2) in the rat. Toxicol Appl Pharmacol. 1981 Mar 15;57(3):401-13.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 0.867, 0.0867 MG/KG.
  • Absorption Disposition Metabolism Elimination (Intravenous)  (S0440)  Completed 
    • Citation: Lynn RK, Wong K, Garvie-Gould C, Kennish JM. Disposition of the flame retardant, tris(1,3-dichloro-2-propyl) phosphate, in the rat. Drug Metab Dispos. 1981 Sep-Oct;9(5):434-41. Pubmed Abstract
    • Citation: Pharmacokinetics of Xenobiotics. Final Report: Tris(1,3-Dichloro-2-Propyl) Phosphate (Fyrol-FR): Disposition in the Rat, Bacterial Mutagenicity and Nephrotoxicity Studies December 1981
    • Rats; Mice
  • Mechanisms (Intravenous)  (S0443)  Completed 
    • Citation: Morales NM, Matthews HB. In vivo binding of the flame retardants tris(2,3-dibromopropyl) phosphate and tris(1,3-dichloro-2-propyl) phosphate to macromolecules of mouse liver, kidney and muscle. Bull Environ Contam Toxicol. 1980 Jul;25(1):34-8.Pubmed Abstract
    • Male Mice
  • C. elegans  (W10923)  Completed 
    • C. elegans: N2
    • Dose: Feeding: 0, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uM Repro: 0, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uM Growth: 0, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uM.

Genetic Toxicology

  • Salmonella  (055416)  Completed 
    •  Positive 
  • Salmonella  (268593)  Completed 
    •  Positive 
  • Salmonella  (422335)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
  • Salmonella  (673999)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
  • Salmonella  (685038)  Completed 
    •  Positive 
  • Salmonella  (719875)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
  • Salmonella  (764028)  Completed 
    •  Positive 
  • Salmonella  (891478)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
  • Salmonella  (970291)  Completed 
    •  Positive