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Testing Status of tris(1,3-Dichloro-2-propyl) phosphate 10923-J

 

CASRN: 13674-87-8

Formula: C9-H15-Cl6-O4-P

Synonyms/Common Names

  • 1,3-Dichloro-2-propanol phosphate (3:1)(9CI)
  • Fyrol FR 2

Known Uses

Flame retardant. In polyesters, rigid urethane foam, resins.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0007)  Completed 
    • Male Rats: F344/N
    • Dose: 0.867, 0.0867 MG/KG.
  • Absorption Disposition Metabolism Elimination (Intravenous)  (S0440)  Completed 
    • Citation: Lynn RK, Wong K, Garvie-Gould C, Kennish JM. Disposition of the flame retardant, tris(1,3-dichloro-2-propyl) phosphate, in the rat. Drug Metab Dispos. 1981 Sep-Oct;9(5):434-41. Pubmed Abstract
    • Citation: Pharmacokinetics of Xenobiotics. Final Report: Tris(1,3-Dichloro-2-Propyl) Phosphate (Fyrol-FR): Disposition in the Rat, Bacterial Mutagenicity and Nephrotoxicity Studies December 1981
    • Rats; Mice
  • Mechanisms (Intravenous)  (S0443)  Completed 
    • Citation: Morales NM, Matthews HB. In vivo binding of the flame retardants tris(2,3-dibromopropyl) phosphate and tris(1,3-dichloro-2-propyl) phosphate to macromolecules of mouse liver, kidney and muscle. Bull Environ Contam Toxicol. 1980 Jul;25(1):34-8.Pubmed Abstract
    • Male Mice
  • C. elegans  (W10923)  Completed 
    • Citation: Behl M, Rice JR, Smith MV, Co CA, Bridge M, Hsieh JH, Freedman JH, Boyd WA. Comparative toxicity of organophosphate flame retardants and polybrominated diphenyl ethers to c. Elegans. Toxicol Sci. 2016 Aug;154(2):241-252Pubmed Abstract
    • C. elegans: N2
    • Dose: Feeding: 0, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uM Repro: 0, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uM Growth: 0, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uM.

Genetic Toxicology

  • Salmonella  (055416)  Completed 
    •  Positive 
  • Salmonella  (268593)  Completed 
    •  Positive 
  • Salmonella  (422335)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
  • Salmonella  (673999)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
  • Salmonella  (685038)  Completed 
    •  Positive 
  • Salmonella  (719875)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
  • Salmonella  (764028)  Completed 
    •  Positive 
  • Salmonella  (891478)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
  • Salmonella  (970291)  Completed 
    •  Positive