National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10924-n

Testing Status of Trifluralin - 10924-N

 

CASRN: 1582-09-8

Formula: C13-H16-F3-N3-O4

Synonyms/Common Names

  • 2,6-Dinitro-N,N-dipropyl-4-(trifluoromethyl)benzenamine (9CI)

Known Uses

Pre-emergence herbicide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00442)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00442)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: 0, 3560, 35600 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00442)  Report Complete 
    • TR-034 (NIH Number: 78-834)  (Peer Review Approval 01/18/1977A )
      Bioassay of Trifluralin for Possible Carcinogenicity (CASRN 1582-09-8)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Positive 
    • Dose: MR: 0, 4125, 8000 (AVG), FR: 0, 4125, 7917 (AVG), MM: 0, 2000, 3744 (AVG), FM: 02740, 5192 (AVG) PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (118061)  Completed 
    • Citation: Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Negative 
  • In Vitro Cytogenetics (CA/SCE)  (143744)  Completed 
    • Citation: Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (259905)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (087290)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.