National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10925-s

Testing Status of Trichlorofluoromethane - 10925-S

 

CASRN: 75-69-4

Formula: C-Cl3-F

Synonyms/Common Names

  • Fluorochloroform

Known Uses

Aerosol propellant; solvent; refrigerant. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C04637)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Gavage)  (C04637)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: 0, 1000, 10000 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C04637)  Report Complete 
    • TR-106 (NIH Number: 78-1356)  (Peer Review Approval 03/06/1978A )
      Bioassay of Trichlorofluoromethane for Possible Carcinogenicity (CASRN 75-69-4)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Inadequate Study 
      • Female Rats Inadequate Study 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: MR: 0, 488, 977 (AVG), FR: 0, 538, 1077 (AVG), M: 0, 1962, 3925 (AVG) MG/KG/50 PER GROUP.

Genetic Toxicology

  • Salmonella  (714291)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
  • Salmonella  (A12906)  Completed 
    •  Negative 
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