National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10926-w

Testing Status of Toxaphene - 10926-W

 

CASRN: 8001-35-2

Formula: C10-H10-Cl8

Synonyms/Common Names

  • Camphechlor

Known Uses

Insecticide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00259)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00259)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0,160,2560 (AVG), M: 0,40,1280 (AVG) PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00259)  Report Complete 
    • TR-037 (NIH Number: 79-837)  (Peer Review Approval 08/31/1978A )
      Bioassay of Toxaphene for Possible Carcinogenicity (CASRN 8001-35-2)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Equivocal 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: MR: 0,556,1112 (AVG), FR: 0,540,1080 (AVG), M: 0,99,198 (AVG) PPM/50 PER GROUP.

Genetic Toxicology

  • Salmonella  (907413)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
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