National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10927-a

Testing Status of Tolbutamide - 10927-A

 

CASRN: 64-77-7

Formula: C12-H18-N2-O3-S

Synonyms/Common Names

  • N-((Butylamino)carbonyl)-4-methylbenzenesulfonamide (9CI)

Known Uses

Hypoglycemic

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01763)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C01763)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: MR: 0, 300, 6000, FR: 0, 12000, 24000, MM: 0, 500, 10000, FM: 0, 20000, 40000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C01763)  Report Complete 
    • TR-031 (NIH Number: 77-831)  (Peer Review Approval 09/26/1977A )
      Bioassay of Tolbutamide for Possible Carcinogenicity (CASRN 64-77-7)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 12000, 24000, M: 0, 25000, 50000 PPM/35 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (481185)  Completed 
    • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (465250)  Completed 
    • Mice
    •  Negative 
  • Salmonella  (736579)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.