National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10928-e

Testing Status of Tolazamide - 10928-E

 

CASRN: 1156-19-0

Formula: C14-H21-N3-O3-S

Synonyms/Common Names

  • N-(((Hexahydro-1H-azepin-1-yl)-amino)carbonyl)-4-methylbenzenesulfonamide (9CI)

Known Uses

Hypoglycemic agent

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03327)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03327)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: FR: 0, 2500, 40000, FM: 0, 2000, 50000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03327)  Report Complete 
    • TR-051 (NIH Number: 78-1301)  (Peer Review Approval 03/06/1978A )
      Bioassay of Tolazamide for Possible Carcinogenicity (CASRN 1156-19-0)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0, 5000, 10000 PPM/35 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (225955)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (255587)  Completed 
    • Mice
    •  Negative 
  • Salmonella  (352518)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Equivocal 
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